Abstract | BACKGROUND: The transmissible agent of Creutzfeldt-Jakob disease (CJD) is not readily destroyed by conventional sterilization and transmissions by surgical instruments have been reported. Decontamination studies have been carried out thus far on solutions or suspensions of the agent and may not reflect the behavior of surface-bound infectivity. MATERIALS AND METHODS: RESULTS:
Stainless steel wire (0.15 x 5 mm) exposed to scrapie-infected mouse brain homogenate and washed extensively with PBS retained the equivalent of about 10(5) LD50 units per segment. Treatment with 10% formaldehyde for 1 hr reduced this value by only about 30-fold. CONCLUSIONS:
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Authors | E Zobeley, E Flechsig, A Cozzio, M Enari, C Weissmann |
Journal | Molecular medicine (Cambridge, Mass.)
(Mol Med)
Vol. 5
Issue 4
Pg. 240-3
(Apr 1999)
ISSN: 1076-1551 [Print] England |
PMID | 10448646
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Prions
- Stainless Steel
- Formaldehyde
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Topics |
- Animals
- Disease Transmission, Infectious
- Disinfection
(methods)
- Formaldehyde
(pharmacology)
- Mice
- Prions
(metabolism, pathogenicity)
- Protein Binding
- Scrapie
(prevention & control, transmission)
- Stainless Steel
(adverse effects)
- Surgical Instruments
(adverse effects)
- Virulence
(drug effects)
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