Abstract | BACKGROUND: Data concerning appropriate treatment in panic disorder following an initial response to acute therapy are limited. AIMS: METHOD: Patients who responded to acute fluoxetine treatment were randomised to 24 weeks of continued fluoxetine or placebo. RESULTS:
Fluoxetine responders randomised to continue on their acute-phase fluoxetine dose experienced statistically significant improvement in panic attack frequency and phobia rating scale score over 24 weeks of therapy, while those switched to placebo experienced statistically significant worsening in Hamilton Anxiety (HAM-A), Hamilton Depression (HAM-D) and SCL-90-R rating scores. CONCLUSIONS:
Fluoxetine was associated with improved clinical outcomes compared with placebo during continuation therapy.
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Authors | D Michelson, M Pollack, R B Lydiard, R Tamura, R Tepner, G Tollefson |
Journal | The British journal of psychiatry : the journal of mental science
(Br J Psychiatry)
Vol. 174
Pg. 213-8
(Mar 1999)
ISSN: 0007-1250 [Print] England |
PMID | 10448445
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Placebos
- Fluoxetine
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Topics |
- Adult
- Antidepressive Agents, Second-Generation
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Fluoxetine
(therapeutic use)
- Humans
- Male
- Panic Disorder
(drug therapy)
- Placebos
- Recurrence
- Single-Blind Method
- Treatment Outcome
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