Enterobacterial infection modulates major histocompatibility complex class I expression on mononuclear cells.

Abstract

Major histocompatibility complex (MHC) class I expression is reduced in several viral infections, but it is not known whether the same happens during infections caused by intracellular enterobacteria. In this study, the expression of MHC class I antigens on peripheral blood mononuclear cells (PBMC) from 16 patients with Salmonella, Yersinia, or Klebsiella infection was investigated. During or after the acute infection, the expression of MHC class I antigens was markedly decreased in eight patients, all with genotype HLA-B27, and six out of eight with reactive arthritis (ReA). A significant decrease of monomorphic MHC class I was found in three patients, of HLA-B27 in eight (P<0.05) and of HLA-A2 in two. However, patients negative for the HLA-B27 genotype, or healthy HLA-B27-positive individuals, did not have a significant decrease of MHC class I antigens. During the decreased expression on the cell surface, intracellular retention of MHC class I antigens was observed, whereas HLA-B27 mRNA levels did not vary significantly. This is the first evidence that enterobacterial infection may down-regulate expression of MHC class I molecules in vivo and that down-regulation is predominant in patients with the HLA-B27 genotype.

• Authors: J Kirveskari, Q He, M Leirisalo-Repo, O Mäki-Ikola, M Wuorela, A Putto-Laurila, K Granfors
• Journal: Immunology (Immunology) Vol. 97 Issue 3 Pg. 420-8 (Jul 1999) ISSN: 0019-2805 [Print] England
• PMID: 10447763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Surface
• HLA-A2 Antigen
• HLA-B27 Antigen
• Histocompatibility Antigens Class I
• PHB2 protein, human
• Prohibitins

Topics

• Adolescent
• Adult
• Antigens, Surface (blood)
• Arthritis, Reactive (immunology)
• Down-Regulation
• Enterobacteriaceae Infections (immunology)
• Female
• Follow-Up Studies
• HLA-A2 Antigen (blood)
• HLA-B27 Antigen (blood)
• Histocompatibility Antigens Class I (blood)
• Humans
• Klebsiella Infections (immunology)
• Leukocytes, Mononuclear (immunology)
• Male
• Middle Aged
• Monocytes (immunology)
• Prohibitins
• Salmonella Infections (immunology)
• Salmonella typhimurium
• Yersinia Infections (immunology)
• Yersinia enterocolitica