No support for HLA-DQ encoded susceptibility in rheumatoid arthritis.

Abstract

OBJECTIVE:

To test predictions based on data from immunogenetic and peptide-binding studies of collagen-induced arthritis in mice, in which it has been suggested that susceptibility to rheumatoid arthritis (RA) might be determined by the interaction between susceptibility alleles at the HLA-DQ locus and protective alleles at the HLA-DRB1 locus (including susceptibility effects for HLA-DQ7 and DQ8).

METHODS:

Predictions based on these models were tested in 166 healthy controls and 167 patients with RA, all of whom were typed for HLA-DRB1 and HLA-DQ alleles.

RESULTS:

In this population, HLA-DQ7 did not encode an increased risk for RA. This lack of susceptibility effect of HLA-DQ7 could not be attributed to competing HLA-DQ susceptibility alleles, protective HLA-DRB1 alleles, or the absence of DQA1*0301.

CONCLUSION:

These observations do not support the DR/DQ hypothesis in its present form.

• Authors: N de Vries, C van Elderen, H Tijssen, P L van Riel, L B van de Putte
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 42 Issue 8 Pg. 1621-7 (Aug 1999) ISSN: 0004-3591 [Print] United States
• PMID: 10446860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQA1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Alleles
• Arthritis, Rheumatoid (genetics, immunology)
• Genetic Predisposition to Disease
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Humans