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UFT/oral calcium folinate plus radiation in pancreatic cancer.

Abstract
A phase I, single-center, open-label, dose-escalation study (University of Alabama [UAB] 9614) has been undertaken to evaluate the feasibility and safety of uracil and tegafur (in a molar ratio of 4:1 [UFT]) plus oral calcium folinate (Orzel) plus radiotherapy in patients with pancreatic cancer. A total of 11 patients with a median age of 59 years have been treated for 35 days with 150 mg/m2/day of UFT and 90 mg/day of oral calcium folinate, divided into three daily doses. Radiotherapy began on day 1, to a total dose of 45 Gy at 1.8 Gy per day (for approximately 5 weeks). Dose escalation of UFT will be performed until the maximum tolerated dose is defined. Overall, therapy has been well tolerated and the maximum tolerated dose has not yet been reached.
AuthorsF Robert, D Raben, S Spencer
JournalOncology (Williston Park, N.Y.) (Oncology (Williston Park)) Vol. 13 Issue 7 Suppl 3 Pg. 127-8 (Jul 1999) ISSN: 0890-9091 [Print] United States
PMID10442381 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Tegafur
  • Uracil
  • Leucovorin
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Follow-Up Studies
  • Humans
  • Leucovorin (therapeutic use)
  • Middle Aged
  • Pancreatic Neoplasms (drug therapy, mortality, radiotherapy)
  • Radiotherapy, Adjuvant
  • Safety
  • Survival Rate
  • Tegafur (therapeutic use)
  • Treatment Outcome
  • Uracil (therapeutic use)

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