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Deuterium NMR tissue perfusion measurements using the tracer uptake approach: II. Comparison with microspheres in tumors.

Abstract
Whole-volume tumor perfusion measured using nuclear magnetic resonance (NMR) observation of deuterated water uptake after intravenous injection and a common arterial input function (AIF) derived from AIF estimates in a small set of animals was compared with perfusion measured by the commonly used microsphere method in rat 9L gliosarcomas. Tumor perfusion estimated with this optimized NMR technique using an appropriate common AIF (i.e., taking into account the duration of anesthesia) correlates highly (n = 13, P = 0. 001) with that measured by the microsphere method, yielding no significant differences (P = 0.5, paired Student's t-test). Thus, the optimized NMR method can be used for repeatable, non-invasive, and quantitative measurements of tumor perfusion. Magn Reson Med 42:240-247, 1999.
AuthorsN E Simpson, J L Evelhoch
JournalMagnetic resonance in medicine (Magn Reson Med) Vol. 42 Issue 2 Pg. 240-7 (Aug 1999) ISSN: 0740-3194 [Print] United States
PMID10440948 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
CopyrightCopyright 1999 Wiley-Liss, Inc.
Chemical References
  • Fluorescent Dyes
  • Deuterium
Topics
  • Anesthesia, Inhalation
  • Animals
  • Deuterium
  • Fluorescent Dyes
  • Gliosarcoma (blood supply)
  • Linear Models
  • Magnetic Resonance Spectroscopy (methods)
  • Male
  • Microspheres
  • Neoplasm Transplantation
  • Rats
  • Rats, Inbred F344
  • Regional Blood Flow
  • Tumor Cells, Cultured

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