[Urine C-peptide excretion in hypocaloric states and factors affecting its excretion].

Abstract

Recent evidence suggests that hyperinsulinemia may contribute to the development of various risk factors of atherosclerosis. To examine the effects of energy intake on insulin secretion, 24-h urine C-peptide was measured in twelve women with rheumatoid arthritis who were not taking any medicine and stayed in Koda hospital for a diet therapy which lasted 55 days. They were basically placed on a 1200 kcal/day vegan diet combined with three 3-5-day fasting periods (200 kcal/day). Urine C-peptide excretion markedly decreased from 31-40 to 8-14 micrograms/day during the fasting periods. Among the anthropometric variables examined, the average level of urine C-peptide excretions measured in the fasting periods showed a significant correlation with the percentage and the amount of body fat. However, such correlation was not observed while the calorie intake was 1200 kcal. No clinical laboratory parameter showed a significant correlation with urinary C-peptide excretion. These results suggest that the major determinant of urine C-peptide excretion is food intake and that hyperinsulinemia could be easily improved by restricting energy intake.

• Authors: A Futamura, Y Hashimoto, S Okubo, T Aihara, H Watanabe, A Fujita, M Koda, K Nakahara
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 47 Issue 6 Pg. 566-70 (Jun 1999) ISSN: 0047-1860 [Print] Japan
• PMID: 10434575 (Publication Type: English Abstract, Journal Article)

Chemical References

• C-Peptide

Topics

• Arthritis, Rheumatoid (diet therapy)
• C-Peptide (urine)
• Energy Intake
• Female
• Humans
• Hyperinsulinism (diet therapy)