Trazodone in burning mouth pain: a placebo-controlled, double-blind study.

Abstract

AIMS:

An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain.

METHODS:

Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.

RESULTS:

There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness.

CONCLUSION:

In this controlled trial, trazodone failed to relieve burning mouth pain.

• Authors: T Tammiala-Salonen, H Forssell
• Journal: Journal of orofacial pain (J Orofac Pain) Vol. 13 Issue 2 Pg. 83-8 ( 1999) ISSN: 1064-6655 [Print] United States
• PMID: 10425979 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents, Second-Generation
• Trazodone

Topics

• Adult
• Aged
• Analysis of Variance
• Antidepressive Agents, Second-Generation (therapeutic use)
• Burning Mouth Syndrome (drug therapy)
• Chronic Disease
• Double-Blind Method
• Facial Pain (drug therapy)
• Female
• Humans
• Middle Aged
• Pain Measurement
• Trazodone (therapeutic use)
• Treatment Failure