Pain, allodynia, and serum serotonin level in orofacial pain of muscular origin.

Abstract

AIMS:

This study was conducted to investigate the serum level of serotonin (S-5-HT) in patients with temporomandibular disorders (TMD) of muscular origin, i.e., localized myalgia, and to compare it to that found in healthy individuals and patients with fibromyalgia. A second aim was to investigate the association between S-5-HT and pain parameters.

METHODS:

Twenty patients with localized myalgia participated in the study. Twenty age- and gender-matched healthy individuals and twenty patients with fibromyalgia served as controls. The participants were examined clinically as to the condition of the temporomandibular region and S-5-HT.

RESULTS:

The levels of S-5-HT did not differ significantly between the groups. However, in patients with localized myalgia there was a negative correlation between S-5-HT and tenderness of the temporomandibular muscles.

CONCLUSION:

The results of this study indicate that allodynia of orofacial muscles in patients with TMD is significantly related to S-5-HT concentration.

• Authors: M Ernberg, B Hedenberg-Magnusson, P Alstergren, T Lundeberg, S Kopp
• Journal: Journal of orofacial pain (J Orofac Pain) Vol. 13 Issue 1 Pg. 56-62 ( 1999) ISSN: 1064-6655 [Print] United States
• PMID: 10425969 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Free Radical Scavengers
• Serotonin

Topics

• Adult
• Analysis of Variance
• Case-Control Studies
• Facial Muscles (chemistry)
• Facial Pain (blood)
• Female
• Fibromyalgia (blood)
• Free Radical Scavengers (blood)
• Humans
• Male
• Masticatory Muscles (chemistry)
• Middle Aged
• Pain Measurement
• Serotonin (blood)
• Statistics, Nonparametric
• Temporomandibular Joint Dysfunction Syndrome (blood)