[The future of antifungal agents. Non azole antifungal agents].

Abstract

We investigated the efficacy of non-azole antifungal agents. Long circulating immunoliposomal amphotericin B was potent in murine invasive pulmonary aspergillosis. The concentration of AMPH-B was still high in the lung after 6 hours of 34A-PEG-liposomal AMPH-B. Lipid nanosphere amphotericin B (NS-718) showed efficacy against pulmonary aspergillosis in rats and pulmonary cryptococcosis in mice. The renal toxicity of NS-718 was estimated to be lower than that of AMPH-B from the results of the toxicity study in the rat infusion model. FK 463, a novel (1,3)-beta-D-glucan synthase inhibitor, showed efficacy against azole-resistant Candida albicans in murine experimental disseminated candidiasis. FK463 could be a promising drug and the therapy of choice for azole resistant C. albicans infection.

• Authors: S Maesaki, M A Hossain, E Sasaki, K Hashiguchi, Y Higashiyama, Y Yoshitsugu, K Tomono, T Tashiro, S Kohno
• Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology (Nihon Ishinkin Gakkai Zasshi) Vol. 40 Issue 3 Pg. 157-61 ( 1999) ISSN: 0916-4804 [Print] Japan
• PMID: 10423510 (Publication Type: Journal Article, Review)

Chemical References

• Antifungal Agents
• Drug Carriers
• Echinocandins
• Lipopeptides
• Lipoproteins
• Liposomes
• Membrane Proteins
• Peptides, Cyclic
• Schizosaccharomyces pombe Proteins
• Amphotericin B
• Flucytosine
• Glucosyltransferases
• 1,3-beta-glucan synthase
• Micafungin

Topics

• Amphotericin B (administration & dosage, pharmacology)
• Animals
• Antifungal Agents (administration & dosage, pharmacology)
• Drug Carriers
• Echinocandins
• Flucytosine
• Fungi (enzymology)
• Glucosyltransferases (antagonists & inhibitors)
• Lipopeptides
• Lipoproteins (pharmacology)
• Liposomes
• Membrane Proteins
• Micafungin
• Mice
• Mycoses (drug therapy)
• Peptides, Cyclic (pharmacology)
• Rats
• Schizosaccharomyces pombe Proteins