A patient with bilateral primary adrenal lymphoma, presenting with fever of unknown origin and achieving long-term disease-free survival after resection and chemotherapy.

Abstract

Primary adrenal lymphoma is extremely rare. We describe a 64-year-old female patient who presented with fever of unknown origin. Imaging studies demonstrated bilateral bulky adrenal masses. She underwent bilateral adrenalectomy and the pathological diagnosis was large cell immunoblastic (B-cell) lymphoma. She received adjuvant combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone in the following 6 months. She has been relapse free for 52 months. To the best of our knowledge, this case has the longest disease-free survival among those reported. The present case indicated that primary adrenal lymphoma should be included in the differential diagnosis of fever of unknown origin and/or suprarenal mass. Chemotherapy following surgical resection may be considered the treatment of choice.

• Authors: H C Wu, L Y Shih, T C Chen, S H Chu, C C Tsai
• Journal: Annals of hematology (Ann Hematol) Vol. 78 Issue 6 Pg. 289-92 (Jun 1999) ISSN: 0939-5555 [Print] Germany
• PMID: 10422633 (Publication Type: Case Reports, Journal Article)

Topics

• Adrenal Cortex (pathology)
• Adrenal Gland Neoplasms (diagnosis, drug therapy, surgery)
• Diagnosis, Differential
• Disease-Free Survival
• Female
• Fever of Unknown Origin (diagnosis)
• Humans
• Lymphoma, Large-Cell, Immunoblastic (diagnosis, drug therapy, surgery)
• Middle Aged
• Prognosis
• Time Factors