HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Correlation between antigenemia of Paracoccidioides brasiliensis and inhibiting effects of plasma in patients with paracoccidioidomycosis.

Abstract
Metabolites produced by pathogenic fungi may be involved in the pathogenesis of fungal infections consequently altering the defence mechanisms of the host. In this study the levels of Paracoccidioides brasiliensis antigens detected in the plasma of patients with paracoccidioidomycosis correlated with the suppression index detected by the low mitogenic response of peripheral blood mononuclear cells (PBMC) to phytohaemaglutinin (PHA). This inhibitory effect on lymphoproliferation was observed in the plasma of 58% of the patients, suggesting the presence of inhibitory factors. Plasma samples from paracoccidioidomycosis patients having or not having inhibitory factors showed no significant effect on chromosomes of lymphocytes from healthy individuals. However, these plasmas had a suppressive activity on the blastogenic response of these lymphocytes stimulated with PHA, that was independent of a cytotoxic effect. P. brasiliensis antigens added to the proliferative response of PBMC from healthy individuals stimulated or not stimulated with PHA showed a dose-dependent suppressor effect, reproducing the inhibitory effect of patients' plasma. We suggest that the antigens of P. brasiliensis present in the plasma of patients, even at low concentrations, can play an important role in the reduction of the cellular immune response and in the genesis of the immunoregulatory disturbances observed in paracoccidioidomycosis.
AuthorsM F Sugizaki, M T Peraçoli, M J Mendes-Giannini, A M Soares, C S Kurokawa, R P Mendes, S A Marques, D V Freire-Maia
JournalMedical mycology (Med Mycol) Vol. 37 Issue 4 Pg. 277-84 (Aug 1999) ISSN: 1369-3786 [Print] England
PMID10421863 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Fungal
  • Immune Sera
Topics
  • Adolescent
  • Adult
  • Aged
  • Aneuploidy
  • Antigens, Fungal (blood, immunology, pharmacology)
  • Cell Division (drug effects, immunology)
  • Female
  • Humans
  • Immune Sera (immunology, pharmacology)
  • Lymphocytes (cytology, drug effects, immunology)
  • Male
  • Middle Aged
  • Paracoccidioides (immunology)
  • Paracoccidioidomycosis (blood, immunology)
  • Skin Tests

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: