Abstract | BACKGROUND: METHODS AND RESULTS: In the initial experiment, 6 juvenile swine were given 0.5 mg/kg IV glibenclamide, a selective inhibitor of the K(+)( ATP) channel, and chest impact was given on the QRS. The results of these strikes were compared with animals in which no glibenclamide was given. In the second phase, 20 swine were randomized to receive glibenclamide or a control vehicle (in a double-blind fashion), with chest impact delivered just before the T-wave peak. With QRS impacts, the maximal ST elevation was significantly less in those animals given glibenclamide (0.16+/-0.10 mV) than in controls (0.35+/-0.20 mV; P=0.004). With T-wave impacts, the animals that received glibenclamide had significantly fewer occurrences of ventricular fibrillation (1 episode in 27 impacts; 4%) than controls (6 episodes in 18 impacts; 33%; P=0.01). CONCLUSIONS: In this experimental model of commotio cordis, blockade of the K(+)( ATP) channel reduced the incidence of ventricular fibrillation and the magnitude of ST-segment elevation. Therefore, selective K(+)( ATP) channel activation may be a pivotal mechanism in sudden death resulting from low-energy chest-wall trauma in young people during sporting activities.
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Authors | M S Link, P J Wang, B A VanderBrink, E Avelar, N G Pandian, B J Maron, N A Estes 3rd |
Journal | Circulation
(Circulation)
Vol. 100
Issue 4
Pg. 413-8
(Jul 27 1999)
ISSN: 1524-4539 [Electronic] United States |
PMID | 10421603
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Potassium Channel Blockers
- Potassium Channels
- Adenosine Triphosphate
- Glyburide
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Topics |
- Adenosine Triphosphate
(physiology)
- Animals
- Death, Sudden, Cardiac
(etiology)
- Electrocardiography
- Glyburide
(pharmacology)
- Potassium Channel Blockers
- Potassium Channels
(metabolism)
- Swine
- Thoracic Injuries
(complications, metabolism, physiopathology)
- Ventricular Fibrillation
(etiology, prevention & control)
- Wounds, Nonpenetrating
(complications, metabolism, physiopathology)
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