Abstract | AIMS/BACKGROUND: METHODS: Ninety-nine subjects were enrolled: 50 were treated with lomefloxacin 0.3% eye drops twice daily and 49 with tobramycin 0.3% eye drops 4 times daily. In all patients, conjunctival swabbing and assessment of objective signs and of subjective symptoms were performed. RESULTS: There was no statistical difference for any individual sign or symptom or for the sum score of either key or other signs and symptoms at any of the examination days. The sum score of both key and other signs and symptoms decreased in both groups at day 3-4 as compared to baseline values (p < 0.0001). The decrease in both these scores continued significantly from day 3-4 to day 7-8 (p < 0.05) and was similar in the two treatment groups (p > 0.4). The lowest resistance rate was seen in lomefloxacin (3.5%) and in neomycin (7.0%), while tobramycin showed resistance in 10 out of 88 resistance strains (11.4%). CONCLUSION:
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Authors | P E Gallenga, L Lobefalo, L Colangelo, G Della Loggia, N Orzalesi, P Velati, E Bujtar, F Ponte, S Damiani, M G Bucci, S Bonini, M R Curatola, L A Palma, L Bonomi, L Tomazzoli Gerosa, A Pagliarusco, E Milan, A Jauch |
Journal | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
(Ophthalmologica)
Vol. 213
Issue 4
Pg. 250-7
( 1999)
ISSN: 0030-3755 [Print] Switzerland |
PMID | 10420109
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Fluoroquinolones
- Ophthalmic Solutions
- Quinolones
- lomefloxacin
- Tobramycin
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Bacteria
(drug effects, growth & development, isolation & purification)
- Child
- Colony Count, Microbial
- Conjunctiva
(microbiology)
- Conjunctivitis, Bacterial
(drug therapy, microbiology)
- Double-Blind Method
- Female
- Fluoroquinolones
- Follow-Up Studies
- Haemophilus Infections
(drug therapy, microbiology)
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
- Prospective Studies
- Quinolones
(administration & dosage, therapeutic use)
- Staphylococcal Infections
(drug therapy, microbiology)
- Streptococcal Infections
(drug therapy, microbiology)
- Tobramycin
(administration & dosage, therapeutic use)
- Treatment Outcome
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