HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Following metastatic placental site trophoblastic tumor with urine beta-core fragment.

AbstractOBJECTIVE:
We document a case with metastatic placental site trophoblastic tumor in a 47-year-old postmenopausal women.
METHODS:
beta-core fragment was measured in urine using the Triton UGP kit. hCG was also measured using the Bayer Immuno-1hCG assay (at Memorial Sloan-Kettering Cancer Center).
RESULTS:
Over 2 years the patient underwent two courses of chemotherapy and two debulking operations. During this time, hCG levels decreased from 227 to 4.1 mIU/ml. hCG levels were close to the limit of detection (<3 mIU/ml), indicating complete or near-complete regression of disease. At this point urine beta-core fragment levels were determined. High levels were detected 7.9 fmol/ml, consistent with the continued existence of tumor (>1.9 fmol/ml). High-dose chemotherapy (CEM) was started with stem cell harvesting. In the following weeks hCG levels failed to identify the tumor (4.1 to <3 mIU/ml). In the first week (during therapy) beta-core fragment levels increased (12 fmol/ml), and in the following weeks (after therapy) levels regressed to 1.2 fmol/ml.
CONCLUSION:
Urine beta-core fragment may be a useful tumor maker when serum hCG levels are near to or below the limit of detection.
AuthorsK Rinne, S Shahabi, L Cole
JournalGynecologic oncology (Gynecol Oncol) Vol. 74 Issue 2 Pg. 302-3 (Aug 1999) ISSN: 0090-8258 [Print] United States
PMID10419751 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 1999 Academic Press.
Chemical References
  • Biomarkers, Tumor
  • Chorionic Gonadotropin
  • Chorionic Gonadotropin, beta Subunit, Human
  • Peptide Fragments
  • urinary gonadotropin fragment
Topics
  • Biomarkers, Tumor (urine)
  • Chorionic Gonadotropin (urine)
  • Chorionic Gonadotropin, beta Subunit, Human (urine)
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms (secondary, urine)
  • Peptide Fragments (urine)
  • Trophoblastic Tumor, Placental Site (secondary, urine)
  • Uterine Neoplasms (urine)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: