Paraneoplastic cicatricial pemphigoid.

Abstract

We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.

• Authors: J Setterfield, P J Shirlaw, Z Lazarova, B M Bryant, B S Bhogal, K Harman, S J Challacombe, M M Black
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 141 Issue 1 Pg. 127-31 (Jul 1999) ISSN: 0007-0963 [Print] England
• PMID: 10417528 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Cell Adhesion Molecules
• Complement C3
• Immunoglobulin G
• kalinin

Topics

• Adult
• Carcinoma, Non-Small-Cell Lung (immunology, pathology)
• Cell Adhesion Molecules (analysis)
• Complement C3 (analysis)
• Female
• Fluorescent Antibody Technique, Direct
• Humans
• Immunoglobulin G (analysis)
• Lung Neoplasms (immunology, pathology)
• Microscopy, Immunoelectron
• Paraneoplastic Syndromes (immunology, pathology)
• Pemphigoid, Benign Mucous Membrane (immunology, pathology)
• Skin (immunology, pathology)