P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury.

Abstract

We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

• Authors: S G Soriano, Y F Wang, D D Wagner, P S Frenette
• Journal: Brain research (Brain Res) Vol. 835 Issue 2 Pg. 360-4 (Jul 24 1999) ISSN: 0006-8993 [Print] Netherlands
• PMID: 10415396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 1999 Elsevier Science B.V.

Chemical References

• E-Selectin
• P-Selectin

Topics

• Animals
• Cerebral Infarction (genetics, pathology)
• E-Selectin (genetics)
• Genetic Engineering
• Genetic Predisposition to Disease
• Ischemic Attack, Transient (genetics, pathology)
• Mice
• Mice, Transgenic
• Necrosis
• P-Selectin (genetics)
• Reperfusion Injury (genetics, pathology)