Abstract | BACKGROUND: METHODS: RESULTS: A 21-month clamp of plasma total cholesterol at 6.0 mmol/liter or below was significantly lower than controls (chi 2 = 84.3, P < 0.001), followed 12 aphereses over 6 to 12 weeks in all but three apheresed patients. 1/Cr slopes were unchanged when the 50-day average period of lipopheresis treatments was excluded from analysis. Proteinuria was not reduced, but serum albumin tended to rise (NS). Fibrinogen fell by 29.8%; high-density lipoprotein, apoA1, and Lp(a) were unchanged. Two apheresed patients had a prolonged remission with a reduction of proteinuria to less than 250 mg/24 hr. The reasons for prolonged reduction of total cholesterol include depletion of tissue cholesterol, an improved fractional catabolic rate of very low density lipoprotein (VLDL), increased hepatocyte LDL turnover, and the maintenance of statin therapy. CONCLUSION: Lipopheresis is a safe and effective method for the control of LDL in nephrotic syndrome. Early clamping of total cholesterol in the normal range resulted in a prolonged and significant reduction of LDL compared with controls.
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Authors | C Brunton, Z Varghese, J F Moorhead |
Journal | Kidney international. Supplement
(Kidney Int Suppl)
Vol. 71
Pg. S6-9
(Jul 1999)
ISSN: 0098-6577 [Print] United States |
PMID | 10412726
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticholesteremic Agents
- Apolipoprotein A-I
- Apolipoproteins B
- Cholesterol, HDL
- Cholesterol, LDL
- Lipoprotein(a)
- Simvastatin
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Topics |
- Anticholesteremic Agents
(therapeutic use)
- Apolipoprotein A-I
(blood)
- Apolipoproteins B
(blood)
- Blood Component Removal
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Combined Modality Therapy
- Female
- Humans
- Lipoprotein(a)
(blood)
- Male
- Middle Aged
- Nephrotic Syndrome
(blood, therapy)
- Simvastatin
(therapeutic use)
- Time Factors
- Treatment Outcome
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