Perchloric acid-soluble proteins from goat liver inhibit chemical carcinogenesis of Syrian hamster cheek-pouch carcinoma.

Abstract

Chemically induced Syrian hamster cheek-pouch squamous cell carcinoma is very similar to the corresponding human tumour. This paper describes a blind study in which inhibition of dimethylbenzanthracene-induced cheek-pouch tumours by a goat liver extract denominated UK101 was investigated. Less than 40% of animals treated with UK101 developed tumours compared with 100% of the controls. Intermediate results (80%) were noted in a positive control group treated with Calmette-Guerin bacillus. Immunocytochemical testing of cheek-pouch mucosa by Mib5 showed significantly less proliferating cells in UK101 animals than in the controls. The effect of UK101 was completely reversed when dexamethasone was added in a third control group. A significant difference in complement-mediated cytotoxicity was noted in the sera of UK101-tested and control animals. These findings suggest that an immune mechanism is responsible for the inhibition of hamster cheek-pouch carcinoma by UK101.

• Authors: F Ghezzo, G N Berta, B Bussolati, A Bosio, G Corvetti, F Di Carlo, G Bussolati, R Guglielmone, A Bartorelli
• Journal: British journal of cancer (Br J Cancer) Vol. 79 Issue 1 Pg. 54-8 (Jan 1999) ISSN: 0007-0920 [Print] England
• PMID: 10408693 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Perchlorates
• Proteins
• 9,10-Dimethyl-1,2-benzanthracene
• Dexamethasone

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Animals
• Carcinogens (toxicity)
• Cell Transformation, Neoplastic (drug effects)
• Cheek
• Cricetinae
• Dexamethasone (pharmacology)
• Goats
• Liver (metabolism)
• Male
• Mesocricetus
• Mouth Neoplasms (chemically induced, pathology, prevention & control)
• Perchlorates (chemistry)
• Proteins (antagonists & inhibitors, chemistry, pharmacology)
• Solubility