Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: The MIB-1 index of cancerous specimens (16.2 +/- 10.5%) was significantly higher than that of benign (1.9 +/- 1.6%, p < 0.0001) or PIN (4.0 +/- 4.5%, p < 0.0001) specimens. The percentage of CGA positive cells was significantly lower in normal tissue (1.2 +/- 1.8%) than in PIN (3.5 +/- 2.9%, p = 0.012) or carcinoma (5.4 +/- 4.9%, p = 0.005) lesions. Positive staining for AR was consistently observed in the nuclei of both benign and malignant epithelial cells, but positive cytoplasmic staining was also seen in PIN epithelial cells. No significant difference in FISH detected anomalies were found between PIN and carcinoma specimens. CONCLUSIONS: Our studies concerning proliferative activity, NE differentiation and chromosomal anomalies of prostatic specimens support the hypothesis that PIN is a biologically intermediate stage in the pathogenesis of prostatic carcinoma. The cellular distribution of AR was altered in PIN cells, but the role of AR in PIN is not yet clear.
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Authors | M Tsuji, K Kanda, Y Murakami, Y Kurokawa, H Kanayama, T Sano, S Kagawa |
Journal | The journal of medical investigation : JMI
(J Med Invest)
Vol. 46
Issue 1-2
Pg. 35-41
(Feb 1999)
ISSN: 1343-1420 [Print] Japan |
PMID | 10408155
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Nuclear
- Autoantibodies
- Biomarkers, Tumor
- Chromogranin A
- Chromogranins
- Genetic Markers
- Ki-67 Antigen
- Nuclear Proteins
- Receptors, Androgen
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Topics |
- Aged
- Antigens, Nuclear
- Autoantibodies
(analysis)
- Biomarkers, Tumor
- Centromere
(genetics)
- Chromogranin A
- Chromogranins
(analysis)
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 8
- Genetic Markers
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Ki-67 Antigen
- Male
- Nuclear Proteins
(analysis)
- Prostatic Intraepithelial Neoplasia
(genetics, immunology, metabolism)
- Prostatic Neoplasms
(genetics, immunology, metabolism)
- Receptors, Androgen
(immunology)
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