Abstract | BACKGROUND/AIMS: METHODS: We compared the survival of 169 transplanted patients with two conservatively treated control groups, one of 169 patients matched for prognostic factors (age, cirrhosis severity, bleeding history) and one of 169 simulated patients. RESULTS: The probability of survival to 5 years in the transplanted group was 66% (95% confidence interval 58-74%) vs. 52% (44-60; p = 0.03) in the matched group and 54% (51-57; p = 0.01) in the simulated controls. Transplantation was associated with survival (relative risk = 1.51; p = 0.02), independently of risk score (risk = 2.07; p<0.001), indication, period of inclusion, centre experience, and alcohol abstinence. Patients with severe disease (Pugh C11-15) benefited most in terms of 5-year survival: 58% (44-72) vs. 31% (17-45; p = 0.008) in the matched and 35% (30-40; p<0.001) in the simulated control groups. For patients at lower risk there was no significant difference. CONCLUSIONS:
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Authors | T Poynard, S Naveau, M Doffoel, K Boudjema, C Vanlemmens, G Mantion, M Messner, B Launois, D Samuel, D Cherqui, G Pageaux, P H Bernard, Y Calmus, J P Zarski, J P Miguet, J C Chaput |
Journal | Journal of hepatology
(J Hepatol)
Vol. 30
Issue 6
Pg. 1130-7
(Jun 1999)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 10406193
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Case-Control Studies
- Humans
- Liver Cirrhosis, Alcoholic
(mortality, surgery)
- Liver Transplantation
(methods, mortality)
- Models, Statistical
- Survival Rate
- Treatment Outcome
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