Meningitis or madness: a delicate balance.

Abstract

A child with meningitis who developed a psychosis 2 weeks after commencing treatment with antituberculous therapy is described here. The psychosis resolved with cessation of isoniazid, but the meningitis returned. The meningitis was treated by re-introduction of daily doses of isoniazid, but the psychosis recurred. Successful treatment of the meningitis, with minimal psychotic symptoms, eventually was achieved using isoniazid at 48 h dose intervals. The psychosis resolved completely after completion of therapy for tuberculous meningitis and cessation of isoniazid. This is the first case of isoniazid-associated psychosis reported in a child.

• Authors: T Duke, M Mai
• Journal: Journal of paediatrics and child health (J Paediatr Child Health) Vol. 35 Issue 3 Pg. 319-20 (Jun 1999) ISSN: 1034-4810 [Print] Australia
• PMID: 10404461 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antitubercular Agents
• Isoniazid

Topics

• Antitubercular Agents (administration & dosage, adverse effects)
• Child
• Humans
• Isoniazid (administration & dosage, adverse effects)
• Male
• Psychoses, Substance-Induced
• Tuberculosis, Meningeal (drug therapy)