Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China.

Abstract

IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barré syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barré syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti-GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.

• Authors: N Yuki, T W Ho, Y Tagawa, M Koga, C Y Li, K Hirata, J W Griffin
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 164 Issue 2 Pg. 134-8 (Apr 01 1999) ISSN: 0022-510X [Print] Netherlands
• PMID: 10402024 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantibodies
• Gangliosides
• G(M1) Ganglioside
• IV(4)-galactosyl-N-acetylganglioside GD1a

Topics

• Acute Disease
• Adolescent
• Adult
• Autoantibodies (analysis)
• Axons (pathology)
• Campylobacter Infections (immunology)
• Campylobacter jejuni
• Child
• Child, Preschool
• China
• Female
• G(M1) Ganglioside (immunology)
• Gangliosides (immunology)
• Humans
• Male
• Middle Aged
• Motor Neuron Disease (immunology, pathology)
• Polyradiculoneuropathy (immunology)