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Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection.

Abstract
There are indications that the cytokine interleukin (IL)-10 has a regulatory role in Epstein-Barr virus (EBV)-induced infections. Because the human IL-10 gene demonstrates polymorphism resulting in interindividual differences in cytokine production, the frequencies of the alleles defined by the base exchange polymorphism at the position -1082 (allele 1=G, allele 2=A) were analyzed in EBV-seronegative adults, seropositive adults, and in patients hospitalized because of a severe EBV infection. The frequencies of allele 1 were 0.80, 0.46, and 0.29, respectively. Because this allele is associated with a high IL-10-producing capability, these data suggest that high IL-10 levels protect against EBV infection and, conversely, that low IL-10-producing capability makes individuals more susceptible to a severe EBV infection.
AuthorsM Helminen, N Lahdenpohja, M Hurme
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 180 Issue 2 Pg. 496-9 (Aug 1999) ISSN: 0022-1899 [Print] United States
PMID10395868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interleukin-10
Topics
  • Adult
  • Child
  • Disease Susceptibility
  • Epstein-Barr Virus Infections (immunology, virology)
  • Gene Frequency
  • Herpesvirus 4, Human (immunology, isolation & purification)
  • Humans
  • Interleukin-10 (genetics)
  • Polymorphism, Genetic

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