Efficacy of gatifloxacin in experimental Escherichia coli meningitis.

Abstract

The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime but similar to meropenem therapy (bacterial killing rates at 5 h, 0.83 +/- 0.26, 0. 46 +/- 0.3, and 0.73 +/- 0.17 CFU/ml/h, respectively; P = 0.03 for gatifloxacin versus cefotaxime). At 10 h, seven of eight animals treated with gatifloxacin had <10 CFU/ml in their cerebrospinal fluid, compared with one of seven treated with cefotaxime therapy (P = 0.01). Gatifloxacin was at least as effective as currently available antibiotics in this model of E. coli meningitis.

• Authors: I Lutsar, I R Friedland, H S Jafri, L Wubbel, W Ng, F Ghaffar, G H McCracken Jr
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 43 Issue 7 Pg. 1805-7 (Jul 1999) ISSN: 0066-4804 [Print] United States
• PMID: 10390250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Gatifloxacin

Topics

• Animals
• Anti-Infective Agents (therapeutic use)
• Escherichia coli (drug effects)
• Escherichia coli Infections (drug therapy)
• Fluoroquinolones
• Gatifloxacin
• Male
• Meningitis, Bacterial (drug therapy)
• Microbial Sensitivity Tests
• Rabbits