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Therapeutic efficacy of theophylline in chronic lymphocytic leukemia.

Abstract
Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.
AuthorsD Makower, U Malik, Y Novik, P H Wiernik
JournalMedical oncology (Northwood, London, England) (Med Oncol) Vol. 16 Issue 1 Pg. 69-71 (Apr 1999) ISSN: 1357-0560 [Print] United States
PMID10382946 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Phosphodiesterase Inhibitors
  • Theophylline
  • Cyclic AMP
Topics
  • Antineoplastic Agents (therapeutic use)
  • Apoptosis (drug effects)
  • Cyclic AMP
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy)
  • Middle Aged
  • Phosphodiesterase Inhibitors (therapeutic use)
  • Theophylline (therapeutic use)

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