Abstract | PURPOSE: METHODS: RESULTS: On admission, both groups were similar regarding all parameters evaluated. After five weeks short chain fatty acid-treated patients showed a significant decrease in the number of days with rectal bleeding from the previous week (4.4+/-1.8 to 1.4+/-2.2; P = 0.001) and an improvement of endoscopic score (4.8+/-1.4 to 2.2+/-1.2; P = 0.001). Hemoglobin values were also significantly higher in short chain fatty acid-treated patients (13.1+/-0.9 g/dl vs. 10.7+/-2.1 g/dl; P = 0.02). Mucosal DNA and protein concentrations decreased in both groups but significantly so only in placebo-treated patients (P = 0.05). Changes in histologic parameters were not significant in either group. Although short chain fatty acid-treated patients did not get worse in the next six months, placebo-treated ones gradually improved, and at the end of six months, differences between the two groups were no longer observed. CONCLUSIONS:
Short chain fatty acid enemas can accelerate the process of healing in chronic radiation proctitis, but treatment has to be continuous if a complete and sustained clinical, endoscopic, and histologic response is to be obtained.
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Authors | A Pinto, P Fidalgo, M Cravo, J Midões, P Chaves, J Rosa, M dos Anjos Brito, C N Leitão |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 42
Issue 6
Pg. 788-95; discussion 795-6
(Jun 1999)
ISSN: 0012-3706 [Print] United States |
PMID | 10378604
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Chronic Disease
- Double-Blind Method
- Enema
- Fatty Acids, Volatile
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Proctitis
(drug therapy, etiology)
- Prospective Studies
- Radiation Injuries
(drug therapy)
- Time Factors
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