[Cardiac electrophysiological effect and clinical use of adenosine].

Abstract

A review is provided of the present state of knowledge relating to the cardiac electrophysiological effects of adenosine at ion channel and clinical levels. It is emphasized that intravenous adenosine is highly effective in terminating sinus node, atrioventricular (AV) nodal and AV-reciprocating reentrant tachycardias. In the course of an account of the antiarrhythmic indications of adenosine therapy, the main aspects of the diagnostic use of the nucleoside are briefly discussed. It is pointed out that adenosine treatment may possibly be accompanied by the occurrence of atrial and ventricular proarrhythmias, for at pharmacological dose of 6-12 mg this endogenous cardioprotective and antiarrhythmic agent is not devoid of side-effects.

• Authors: T Fazekas, G Liszkai
• Journal: Orvosi hetilap (Orv Hetil) Vol. 140 Issue 22 Pg. 1219-26 (May 30 1999) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Az adenozin szív-elektrofiziológiai hatásai és klinikai alkalmazása.
• PMID: 10377732 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Arrhythmia Agents
• Adenosine

Topics

• Adenosine (administration & dosage, therapeutic use)
• Anti-Arrhythmia Agents (pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Heart (drug effects)
• Humans
• Injections, Intravenous
• Tachycardia, Sinoatrial Nodal Reentry (drug therapy)