Abstract |
To obtain a better understanding of mandibulo-facial dysostosis and hemicraniofacial microsomia in man, the authors carried out a histologic and scanning electron microscope study of the facial malformations produced in mouse embryos by retinoic acid and methyl-triazene. The administration of 400 mg/kg 13 cis-retinoic acid (RA) to pregnant C57BL mice on day 9 of gestation produced anomalies of the cephalic extremity in the embryos resembling human mandibulo-facial dysostosis. The 64 embryos collected presented hypoplasia of the branchial arches or the snout in 79% of cases, auricular anomalies in 47% and ophthalmic anomalies in 12.5%. Fourteen NMRI mice on day 10.5 of gestation were treated with 1.5 mg (0.5 mg/kg) methyl-triazene (Methyl). The 126 embryos collected had developed a very high percentage of micromandibles and anomalies of both embryonic ears (94.6% to 100%). Finally, although the facial anomalies produced by retinoic acid resemble the human mandibulo-facial dysostosis syndrome, no correlation was found between hemicraniofacial microsomia and the administration of methyl-triazene.
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Authors | R Glineur, S Louryan, A Lemaître, L Evrard, M Rooze, L De Vos |
Journal | Surgical and radiologic anatomy : SRA
(Surg Radiol Anat)
Vol. 21
Issue 1
Pg. 41-7
( 1999)
ISSN: 0930-1038 [Print] Germany |
PMID | 10370992
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Abnormalities, Drug-Induced
(embryology)
- Adolescent
- Animals
- Child
- Facial Asymmetry
(chemically induced, embryology)
- Female
- Humans
- Male
- Mandibulofacial Dysostosis
(chemically induced, embryology)
- Mice
- Mice, Inbred C57BL
- Microscopy, Electron, Scanning
- Pregnancy
- Tretinoin
- Triazenes
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