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Possible synergy of radiotherapy and chemo-immunotherapy in metastatic renal cell carcinoma (RCC).

AbstractPURPOSE:
Bone metastases or local recurrences are widely viewed as poor prognostic signs for successful immunotherapy for metastatic renal cell carcinoma (RCC), and even partial remission is a rarity. We assessed the efficacy of the combination of radio and chemo-immunotherapy for bone metastases or local recurrences form RCC.
MATERIALS AND METHODS:
From February 1994 until September 1997 twelve patients with progressive renal cell carcinoma (9 with bone metastases and 3 with local recurrence) were treated with a combination of chemo-immunotherapy and radio therapy.
RESULTS:
Four out of twelve patients achieved complete remission (CR), one patient had a partial remission (PR), three were stable and four had disease progression under radio therapy and chemo-immunotherapy. Yet three pts. died of the disease. The toxicity symptoms according to WHO ranged between grade 2 and grade 3.
CONCLUSION:
Our data suggest that the combination of radio therapy and chemo-immunotherapy may induce a synergistic antitumor effect for the treatment of bone metastases or local recurrences from renal cell carcinoma.
AuthorsO A Brinkmann, F Bruns, F J Prott, L Hertle
JournalAnticancer research (Anticancer Res) 1999 Mar-Apr Vol. 19 Issue 2C Pg. 1583-7 ISSN: 0250-7005 [Print] Greece
PMID10365150 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Interferon-alpha
  • Interleukin-2
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Bone Neoplasms (secondary, therapy)
  • Carcinoma, Renal Cell (pathology, radiotherapy, therapy)
  • Combined Modality Therapy (adverse effects)
  • Disease Progression
  • Female
  • Fluorouracil (therapeutic use)
  • Follow-Up Studies
  • Humans
  • Immunotherapy
  • Interferon-alpha (therapeutic use)
  • Interleukin-2 (therapeutic use)
  • Kidney Neoplasms (pathology, radiotherapy, therapy)
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Time Factors

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