Although several studies have shown that asymptomatic human immunodeficiency virus
infection elicits an increase in whole body
protein turnover, it is not known whether this increased
protein turnover includes changes in the kinetics of
acute-phase proteins (APPs). To answer this question, we measured 1) the plasma concentrations of four positive (
C-reactive protein, alpha1-antitrypsin,
haptoglobin, and
fibrinogen) and four negative APPs [
albumin,
high-density lipoprotein (HDL)-
apolipoprotein (
apo) A1,
transthyretin, and
retinol-binding protein] and 2) the fractional (FSR) and absolute (ASRs) synthesis rates of three positive and three negative APPs using a constant
intravenous infusion of [2H5]
phenylalanine in five subjects with symptom-free
acquired immunodeficiency syndrome (
AIDS) and five noninfected control subjects. Compared with the values of the controls, the plasma concentrations, FSRs, and ASRs of most positive APPs were higher in the
AIDS group. The negative APPs had faster FSRs in the
AIDS group, there was no difference between the ASRs of the two groups, and only HDL-apoA1 had a lower plasma concentration. These results suggest that symptom-free
AIDS elicits an APP response that is different from
bacterial infections, as the higher concentrations and faster rates of synthesis of the positive APPs are not accompanied by lower concentrations and slower rates of synthesis of most of the negative APPs.