Effectiveness of oxybutynin hydrochloride in the treatment of enuresis nocturna--a clinical and urodynamic study.

Abstract

OBJECTIVE:

To find the efficacy and optimal dosage of oxybutynin HC1 in a group of enuretic children, who were non-responsive to imipramine.

MATERIAL AND METHODS:

Thirty-six patients with enuresis who were non-responsive to imipramine were urodynamically assessed and subsequently treated with oxybutynin hydrochloride (HCl). Patients with inadequate bladder storage function (IBSF) were started on 10-mg daily oxybutynin HCl for one month. If the initial treatment was found to be inadequate, the dose was increased to 15 mg daily. The dose in patients who were non-responsive to 15-mg daily dose was increased to 20-mg daily dose. Patients who were normal urodynamically were treated with a dose of 15 mg daily for one month.

RESULTS:

Before the treatment, 17 patients had IBSF (47.2%). The majority of the patients (88.2%) with IBSF were responsive to the 15-mg daily oxybutynin HCl. The treatment in patients with normal bladder function was generally unsuccessful.

CONCLUSIONS:

Oxybutynin HCl in sufficient dosages seems to be effective in the treatment of enuretic patients with IBSF.

• Authors: A Koşar, N Arikan, C Dinçel
• Journal: Scandinavian journal of urology and nephrology (Scand J Urol Nephrol) Vol. 33 Issue 2 Pg. 115-8 (Apr 1999) ISSN: 0036-5599 [Print] England
• PMID: 10360452 (Publication Type: Journal Article)

Chemical References

• Cholinergic Antagonists
• Mandelic Acids
• oxybutynin

Topics

• Adolescent
• Child
• Cholinergic Antagonists (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Enuresis (drug therapy)
• Humans
• Mandelic Acids (administration & dosage, therapeutic use)
• Time Factors
• Urodynamics (drug effects)