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[Effects of mitotane therapy in dogs with pituitary dependent Cushing syndrome on the adrenal gland size--an ultrasonographic study].

Abstract
The effect of mitotane therapy on adrenal gland size was evaluated in 13 dogs with pituitary dependent hyperadrenocorticism. Ultrasonographic measurements were obtained before and during mitotane therapy. During therapy both adrenal glands were shorter and thinner (median during therapy: left adrenal gland 19.4 mm long, 5.4 mm thick, right adrenal gland 18.1 mm long, 6.1 mm thick) than before mitotane therapy (median before therapy: left adrenal gland 23.6 mm long, 8.3 mm thick, right adrenal gland 21.6 mm long, 8.1 mm thick). Statistical evaluation showed a significant reduction in size. But ultrasonographic measurement of adrenal gland size is not useful in the evaluation of adrenal reserve during mitotane therapy. Inadequate adrenal reserve was not identified and adrenal size measurement by ultrasonography was not helpful to differentiate adequate and inadequate control of adrenal cortisol secretion during mitotane therapy.
AuthorsA Hörauf, C Reusch
JournalSchweizer Archiv fur Tierheilkunde (Schweiz Arch Tierheilkd) Vol. 141 Issue 5 Pg. 239-45 ( 1999) ISSN: 0036-7281 [Print] Switzerland
Vernacular TitleAuswirkungen der Mitotane-Therapie bei Hunden mit hypophysärem Cushing-Syndrom auf die Nebennierengrösse--eine sonographische Studie.
PMID10354742 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Hormonal
  • Mitotane
Topics
  • Adrenal Glands (diagnostic imaging, drug effects)
  • Animals
  • Antineoplastic Agents, Hormonal (pharmacology, therapeutic use)
  • Cushing Syndrome (diagnostic imaging, drug therapy, veterinary)
  • Dog Diseases (diagnostic imaging, drug therapy)
  • Dogs
  • Female
  • Male
  • Mitotane (pharmacology, therapeutic use)
  • Ultrasonography

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