Abstract | BACKGROUND: METHODS: Hematologic and hepatic toxicity was monitored, as well as the occurrence of skin rash, PCP or death. RESULTS: Initial pharmacokinetic data indicated that adequate serum dapsone concentrations were not achieved with the daily 1-mg/kg regimen; the daily dose was then increased to 2 mg/kg. Both short and long term hematologic toxicities were marginally greater in children receiving the daily 2 mg/kg compared with the weekly regimen. Allergic skin rashes were similar in children receiving the daily and weekly regimens (17% in both) and were not associated with prior history of rash with T/S. PCP occurred most frequently with the daily 1-mg/kg regimen (22.0 cases/100 patient years), least frequently with the daily 2-mg/kg regimen (0 case/100 patient years) and at intermediate frequency with the weekly regimen (9.5 cases/100 patient years). More deaths were observed in patients receiving the daily than the weekly regimen (8 vs. 2, respectively), although the deaths were not directly attributable to dapsone treatment. CONCLUSION: Although a weekly dapsone regimen of 4 mg/kg produced less hematologic toxicity than a daily regimen of 2 mg/kg, this advantage was offset by a trend toward higher breakthrough rates of PCP.
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Authors | K McIntosh, E Cooper, J Xu, M Mirochnick, J Lindsey, D Jacobus, L Mofenson, R Yogev, S A Spector, J L Sullivan, H Sacks, A Kovacs, S Nachman, J Sleasman, V Bonagura, J McNamara |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 18
Issue 5
Pg. 432-9
(May 1999)
ISSN: 0891-3668 [Print] United States |
PMID | 10353516
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents
- Dapsone
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Topics |
- AIDS-Related Opportunistic Infections
(prevention & control)
- Anti-Infective Agents
(administration & dosage, adverse effects, therapeutic use)
- Child
- Child, Preschool
- Dapsone
(administration & dosage, adverse effects, therapeutic use)
- Drug Administration Schedule
- Humans
- Infant
- Pneumonia, Pneumocystis
(prevention & control)
- Regression Analysis
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