Portal vein thrombosis in paroxysmal nocturnal haemoglobinuria.

Abstract

A 28-year-old man was hospitalized with nausea, vomiting, abdominal pain and low-grade fever. He had a 6-month history of paroxysmal nocturnal haemoglobinuria (PNH), and laboratory data showed anaemia and liver dysfunction. An abdominal ultrasonography showed ascites and portal vein thrombosis. After receiving antithrombotic treatment, the portal vein thrombosis did not extend. Portal vein thrombosis is very rare but should be considered when we encounter liver dysfunction associated with PNH as well as hepatic vein thrombosis. Ultrasonography is very useful in detecting portal vein thrombosis and facilitating early diagnosis. Warfarin is very effective in preventing exacerbation of portal vein thrombosis in PNH.

• Authors: H Tomizuka, K Hatake, S Kitagawa, K Yamashita, H Arai, Y Miura
• Journal: Acta haematologica (Acta Haematol) Vol. 101 Issue 3 Pg. 149-52 ( 1999) ISSN: 0001-5792 [Print] Switzerland
• PMID: 10352335 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Anticoagulants
• Warfarin

Topics

• Adult
• Anticoagulants (administration & dosage)
• Hemoglobinuria, Paroxysmal (diagnosis, drug therapy, etiology)
• Humans
• Liver Function Tests
• Male
• Portal Vein (diagnostic imaging)
• Tomography, X-Ray Computed
• Ultrasonography
• Venous Thrombosis (complications, diagnosis, drug therapy)
• Warfarin (administration & dosage)