Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil.

Abstract

The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for its oral anti-inflammatory and analgesic activity at the doses of 50 and 100 mg/kg body weight. It produced significant inhibition of carrageenan-induced rat paw edema and of both exudative-proliferative and chronic phases of inflammation in adjuvant arthritic rats at doses of 50 and 100 mg/kg body weight. The oil at both tested doses was found to possess analgesic activity against acetic acid-induced writhing and hot plate reaction in mice.

• Authors: U A Shinde, A S Phadke, A M Nair, A A Mungantiwar, V J Dikshit, M N Saraf
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 65 Issue 1 Pg. 21-7 (Apr 1999) ISSN: 0378-8741 [Print] Ireland
• PMID: 10350366 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Oils
• Plant Extracts
• Carrageenan
• Acetic Acid

Topics

• Acetic Acid (adverse effects)
• Analgesics (therapeutic use)
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Arthritis, Experimental (drug therapy)
• Carrageenan (adverse effects)
• Edema (drug therapy)
• Inflammation (chemically induced)
• Mice
• Oils (therapeutic use)
• Pain Measurement (methods)
• Plant Extracts (therapeutic use)
• Rats