Chilblain lupus erythematosus is associated with antibodies to SSA/Ro.
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| Abstract |
Chilblain lupus erythematosus (CL) of Hutchinson is a subtype of lupus erythematosus (LE) characterized by erythematous lesions induced by cold, damp climates. A number of patients affected by CL eventually develop features of systemic lupus erythematosus (SLE). We report here 9 patients with chilblain cutaneous lesions, 6 of them were affected by SLE and 2 by SCLE. The onset of CL preceded the diagnosis of LE, from 1 to 10 years in 3 cases, it was concurrent in one case and was subsequent in the remaining 4 cases. Raynaud's phenomenon and photosensitivity were other prominent clinical features in patients with CL. Nailfold capillaroscopy revealed pathological changes in every patient examined. ANA and anti-SSA/Ro antibodies were detected in all nine patients. Anti-SSB/La were detected in 2 cases, anti-Sm in one case, and anti-Sm and anti-RNP in a one case. Antibodies to dsDNA and complement consumption were found in the six patients with SLE. The fine specificity of anti-SSA/Ro was determined by immunoblotting: anti-60kD and anti-52 kD were detected in three sera, anti-60kD alone in 5 sera, while one serum did not blot. In conclusion, the present study suggests that chilblain LE is associated with SSA/Ro autoantibodies, as is SCLE, hypergammaglobulinemic purpura and neonatal lupus erythematosus.
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| Authors | F Franceschini, P Calzavara-Pinton, M Quinzanini, I Cavazzana, L Bettoni, C Zane, F Facchetti, P Airò, D P McCauliffe, R Cattaneo |
| Journal | Lupus (Lupus) Vol. 8 Issue 3 Pg. 215-9 ( 1999) ISSN: 0961-2033 [Print] England |
| PMID | 10342714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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