Abstract | BACKGROUND: METHODS: A retrospective review of 169 patients who underwent acoustic neuroma surgery with (n = 75) or without (n = 94) a single dose of intraoperative corticosteroids was performed. Tumor size ranged from 0.4 cm to 6 cm (mean, 2.1; SD, 1.0) The translabyrinthine approach was used in 85% of the patients, and the middle cranial fossa approach was used in 13%. Data were analyzed for differences in postoperative facial function and complication rates. RESULTS: After controlling for differences in tumor size, no significant effects of steroid therapy were found for any of the outcome variables. CONCLUSIONS: This retrospective study showed no apparent benefit from intraoperative steroid use in acoustic neuroma surgery. A prospective, randomized, placebo-controlled trial should be performed to confirm these findings.
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Authors | C A Buchman, M J Fucci, W H Slattery, D E Brackmann, K I Berliner |
Journal | The American journal of otology
(Am J Otol)
Vol. 20
Issue 3
Pg. 386-9
(May 1999)
ISSN: 0192-9763 [Print] United States |
PMID | 10337983
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Dexamethasone
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Topics |
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Cranial Nerve Neoplasms
(drug therapy)
- Dexamethasone
(pharmacology, therapeutic use)
- Dose-Response Relationship, Drug
- Facial Nerve
(drug effects)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Monitoring, Intraoperative
- Neuroma, Acoustic
(drug therapy)
- Postoperative Complications
(diagnosis)
- Retrospective Studies
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