Congenital erythroleukemia in a neonate with severe hypoxic ischemic encephalopathy.

Abstract

We report a case of a neonate who presented with hypoxic ischemic encephalopathy, persistent hypoglycemia and hypotension, intractable metabolic acidosis, renal failure and a coagulopathy but who, at autopsy, was found to have massive infiltration of nonhematopoietic tissues with blasts. The diagnosis of congenital erythroleukemia was confirmed by the detection of glycophorin A, a major erythrocyte membrane protein, on the surface of the blasts. The clinical presentation and course of the case described here have not previously been reported for this extremely rare condition.

• Authors: A Hadjiyannakis, W A Fletcher, D P Lebrun, R C van Wylick, K E Dow
• Journal: American journal of perinatology (Am J Perinatol) Vol. 15 Issue 12 Pg. 689-94 ( 1998) ISSN: 0735-1631 [Print] United States
• PMID: 10333396 (Publication Type: Case Reports, Journal Article)

Topics

• Autopsy
• Brain Ischemia (complications, congenital, pathology, therapy)
• Fatal Outcome
• Humans
• Hypoxia, Brain (complications, congenital, pathology, therapy)
• Infant, Newborn
• Leukemia, Erythroblastic, Acute (complications, congenital, pathology, therapy)
• Male
• Multiple Organ Failure