Abstract |
We have examined the influence of bolus size on efficacy, opioid consumption, side effects and patient satisfaction during i.v. patient-controlled analgesia (PCA) in 60 patients (ASA I-II, aged 32-82 yr) after abdominal surgery. Patients were allocated randomly, in a double-blind manner, to receive PCA with a bolus dose of either piritramide 0.75 mg or 1.5 mg (lockout 5 min) for postoperative pain control. Mean 24 h piritramide consumption differed significantly between groups (11.4 (SD 5.8) mg vs 22.5 (18.3) mg; P = 0.001). There were no significant differences in the number of applied bolus doses, pain scores, pain relief (VAS), sedation, nausea, pruritus and patient satisfaction. We conclude that a PCA regimen with a bolus dose of piritramide 0.75 mg and a lockout time of 5 min was effective in the treatment of postoperative pain, but did not reduce the occurrence of side effects.
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Authors | B Morlion, E Ebner, A Weber, W Finke, C Puchstein |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 82
Issue 1
Pg. 52-5
(Jan 1999)
ISSN: 0007-0912 [Print] England |
PMID | 10325836
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Pirinitramide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analgesia, Patient-Controlled
(methods)
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Male
- Middle Aged
- Pain, Postoperative
(drug therapy)
- Pirinitramide
(administration & dosage, therapeutic use)
- Prospective Studies
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