L-threo-3,4-dihydroxyphenylserine enhances the orthostatic responses of plasma renin activity and angiotensin II in multiple system atrophy.

Abstract

We evaluated the effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on the response of blood pressure and vasoactive factors during head-up tilt in patients with multiple system atrophy (MSA). After the daily oral administration of 300 mg L-threo-DOPS for 2 weeks we observed a significant reduction in the decline of systolic blood pressure during 60 degrees head-up-tilt. In concordance with this result, we detected significant increases in postural changes in plasma renin activity and angiotensin II following L-threo-DOPS treatment. The enhanced responses of these vasoactive mediators by L-threo-DOPS during head-up tilt may contribute to the improvement in orthostatic hypotension in patients with MSA.

• Authors: T Yoshizawa, T Fujita, H Mizusawa, S Shoji
• Journal: Journal of neurology (J Neurol) Vol. 246 Issue 3 Pg. 193-7 (Mar 1999) ISSN: 0340-5354 [Print] Germany
• PMID: 10323317 (Publication Type: Journal Article)

Chemical References

• Angiotensin II
• Renin
• 3,4-dihydroxyphenylserine aldolase
• Aldehyde-Lyases

Topics

• Adult
• Aged
• Aldehyde-Lyases (therapeutic use)
• Angiotensin II (blood, drug effects)
• Blood Pressure (drug effects)
• Female
• Heart Rate (drug effects)
• Humans
• Hypotension, Orthostatic (blood, drug therapy, physiopathology)
• Male
• Middle Aged
• Multiple System Atrophy (blood, complications, physiopathology)
• Renin (blood, drug effects)