[Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen].

Smooth-muscle tumors, benign and malignant, are increasingly recognized in children who are immunocompromised because of HIV infection and organ transplantation. We report a case of an EBV-associated smooth-muscle tumor, of unusual location arising in a seven-year-old post-transplant patient who was previously treated for a lymphoproliferative disease. Five years after liver transplantation, a mesenteric tumor was diagnosed. The tumor was composed of spindle cells with smooth-muscle features. Immunohistochemical analysis was positive for muscle-specific actin and desmin, negative for EBV latent membrane protein (LMP-1). In situ hybridization revealed nuclear EBV sequences. This case underlines the role of EBV infection in the development of unusual smooth-muscle tumors after organ transplantation. The evolution of these rare tumors is uncertain.
AuthorsS Ferlicot, B Bessoud, S Branchereau, C Dubuisson, F Gauthier, M Fabre
JournalAnnales de pathologie (Ann Pathol) Vol. 19 Issue 1 Pg. 46-9 (Mar 1999) ISSN: 0242-6498 [Print] FRANCE
Vernacular TitleTumeur musculaire lisse mésentérique associée au virus d'Epstein-Barr (EBV). A propos d'un cas chez un enfant transplanté hépatique sous FK 506.
PMID10320913 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Tacrolimus
  • Child
  • Herpesvirus 4, Human (isolation & purification)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Liver Transplantation (pathology)
  • Male
  • Mesentery (pathology, virology)
  • Peritoneal Neoplasms (pathology, virology)
  • Smooth Muscle Tumor (pathology, virology)
  • Tacrolimus (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: