Nutritional intake, somatomedin activity and linear growth in children undergoing hemodialysis.

Abstract

Reduced somatomedin activity was uniformly present pre-dialysis in 7 children with end-stage renal disease. Somatomedin activity improved in 6 of the 7 patients following a single 5 hr hemodialysis. Percent normal growth correlated with post-dialysis somatomedin activity in 6 of the 7 children. No correlation was present between percent normal growth and calorie or protein intake. Reduced somatomedin activity in children with end-stage renal disease appears to be due to a circulating uremic inhibitor(s). Somatomedin activity may be a useful in vitro test for adequacy of dialysis in children. Further efforts are necessary to identify the inhibitor(s) of somatomedin activity in uremia.

• Authors: A J Pennisi, L S Phillips, C Uittenbogaart, R B Ettenger, M H Malekzadeh, R N Fine
• Journal: Proceedings of the Clinical Dialysis and Transplant Forum (Proc Clin Dial Transplant Forum) 1976 Nov 19-22 Vol. 6 Pg. 181-3 ISSN: 0094-6044 [Print] United States
• PMID: 1029883 (Publication Type: Journal Article)

Chemical References

• Somatomedins

Topics

• Body Height
• Child
• Child Nutritional Physiological Phenomena
• Child, Preschool
• Female
• Growth
• Humans
• Kidney Failure, Chronic (blood, therapy)
• Male
• Renal Dialysis
• Somatomedins (blood)