Abstract | OBJECTIVE: To evaluate systemic versus epidural opioid administration for analgesia in patients sustaining thoracic trauma. SUMMARY BACKGROUND DATA: METHODS: RESULTS: Twenty-four patients of the 34 enrolled completed the study. Age, injury severity score, thoracic abbreviated injury score, and length of hospital stay did not differ between the two groups. There was no significant difference in plasma levels of IL-1beta, IL-2, IL-6, or TNF-alpha or urinary catecholamines between the two groups at any time point. Epidural analgesia was associated with significantly reduced plasma levels of IL-8 at days 2 and 3, verbal rating score of pain on days 1 and 3, and maximal inspiratory force and tidal volume on day 3 versus PCA. CONCLUSIONS:
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Authors | M R Moon, F A Luchette, S W Gibson, J Crews, G Sudarshan, J M Hurst, K Davis Jr, J A Johannigman, S B Frame, J E Fischer |
Journal | Annals of surgery
(Ann Surg)
Vol. 229
Issue 5
Pg. 684-91; discussion 691-2
(May 1999)
ISSN: 0003-4932 [Print] United States |
PMID | 10235527
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Cytokines
- Morphine
- Lidocaine
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Topics |
- Adolescent
- Adult
- Analgesia, Epidural
- Analgesia, Patient-Controlled
- Analgesics, Opioid
(administration & dosage)
- Cytokines
(blood)
- Female
- Humans
- Lidocaine
(administration & dosage)
- Male
- Middle Aged
- Morphine
(administration & dosage)
- Pain
(drug therapy)
- Prospective Studies
- Respiration
- Thoracic Injuries
(complications)
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