Abstract |
A 39-year-old man experienced cough and dyspnea by right massive pleural effusion. A large tumor was found in the anterior mediastinum and it had invaded the chest wall all around. The diagnosis was invasive thymoma stage IV a by biopsy. His tumor was too large to be resected, so chemotherapy was planned. The tumor responded well to cisplatin + etoposide until day 7, but it relapsed immediately between doses. Hence, we administered cisplatin + vincristine + doxorubicin + etoposide (CODE) with G-CSF for its high-dose intensity. The tumor diminished in size, and the chest wall invasion almost disappeared. An operation was performed. We describe our experience with a case of invasive thymoma which responded to CODE.
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Authors | T Hosokawa, H Maki, T Saito, M Harada, H Isobe |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 26
Issue 5
Pg. 697-701
(Apr 1999)
ISSN: 0385-0684 [Print] Japan |
PMID | 10234303
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Vincristine
- Etoposide
- Doxorubicin
- Cisplatin
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cisplatin
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Drug Administration Schedule
- Etoposide
(administration & dosage)
- Humans
- Male
- Neoplasm Invasiveness
- Pleural Effusion, Malignant
(drug therapy, etiology)
- Thymoma
(drug therapy, pathology)
- Thymus Neoplasms
(drug therapy, pathology)
- Vincristine
(administration & dosage)
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