Abstract | AIM:
Clear cell chondrosarcoma (CCC) is a rare malignant cartilaginous neoplasm of bone. CCC is characterized by clear cells (CCC cells), osteoclasts and osteoblasts. Many important questions concerning the varied histological features of CCC, and the interactions between CCC cells and coexisting osteoclasts and osteoblasts have not been fully investigated and remain controversial. The aim of this study is to clarify and explain the varied histological features and the possible interaction between tumour cells (CCC cells) and stromal cells such as osteoclasts and osteoblasts. METHODS AND RESULTS: CONCLUSION: These observations suggest that CCC cells trigger the varied histological changes in association with several cytokines. The difference of PCNA expression between CCC and chondroblastoma seemed to be related to the biological difference between the two tumours.
|
Authors | F Masui, S Ushigome, K Fujii |
Journal | Histopathology
(Histopathology)
Vol. 34
Issue 5
Pg. 447-52
(May 1999)
ISSN: 0309-0167 [Print] England |
PMID | 10231420
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD68 antigen, human
- PTHLH protein, human
- Parathyroid Hormone-Related Protein
- Platelet-Derived Growth Factor
- Proliferating Cell Nuclear Antigen
- Proteins
- S100 Proteins
- Collagen
- Receptors, Platelet-Derived Growth Factor
|
Topics |
- Adult
- Antigens, CD
(metabolism)
- Antigens, Differentiation, Myelomonocytic
(metabolism)
- Bone Neoplasms
(immunology, metabolism, pathology)
- Chondroblastoma
(immunology, metabolism, pathology)
- Chondrosarcoma
(immunology, metabolism, pathology)
- Collagen
(metabolism)
- Female
- Histiocytes
(immunology, metabolism)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Osteoblasts
(immunology, metabolism)
- Osteoclasts
(immunology, metabolism)
- Parathyroid Hormone-Related Protein
- Platelet-Derived Growth Factor
(metabolism)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Proteins
(metabolism)
- Receptors, Platelet-Derived Growth Factor
(metabolism)
- S100 Proteins
(metabolism)
|