Use of fibrin sealant to reduce bleeding after needle liver biopsy in an anticoagulated canine model: work in progress.

Needle biopsy of the liver is a common diagnostic procedure. Although relatively safe, bleeding remains a potential complication and may occur more frequently in patients with coagulopathy. The purpose of this study was to evaluate the utility of a fibrin sealant in preventing bleeding after a 15-gauge needle biopsy of the liver in a canine model heparinized to simulate coagulopathy.
Fibrin sealant was delivered to biopsy tract sites in eight dogs anticoagulated with heparin (activated clotting time 387 seconds +/- 94) using the same sheath system that was employed to obtain the biopsy specimen.
The results demonstrated complete hemostasis in the sealant-plugged tracts as compared to controls. Continuous bleeding was observed in none of the fibrin sealant-treated sites, compared with all of the control biopsy sites (P = .0078).
These results demonstrate the high degree of efficacy of fibrin sealant delivered through a sheath system in plugging liver biopsy tracts and eliminating bleeding in a severely coagulopathic animal model. This indicates that fibrin sealant use in cutting needle biopsies can reduce major and minor complications associated with the procedure.
AuthorsJ K Falstrom, M M Moore, S H Caldwell, A H Matsumoto, R D Abbott, W D Spotnitz
JournalJournal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 10 Issue 4 Pg. 457-62 (Apr 1999) ISSN: 1051-0443 [Print] United States
PMID10229475 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticoagulants
  • Fibrin Tissue Adhesive
  • Hemostatics
  • Tissue Adhesives
  • Heparin
  • Animals
  • Anticoagulants (administration & dosage, adverse effects)
  • Biopsy, Needle (adverse effects, instrumentation, methods)
  • Disease Models, Animal
  • Dogs
  • Drug Delivery Systems
  • Fibrin Tissue Adhesive (administration & dosage, chemical synthesis, therapeutic use)
  • Hemorrhage (prevention & control)
  • Hemostatics (administration & dosage, chemical synthesis, therapeutic use)
  • Heparin (administration & dosage, adverse effects)
  • Liver (pathology)
  • Liver Diseases (prevention & control)
  • Needles
  • Syringes
  • Tissue Adhesives (chemical synthesis, therapeutic use)

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