Use of fibrin sealant to reduce bleeding after needle liver biopsy in an anticoagulated canine model: work in progress.

Abstract

PURPOSE:

Needle biopsy of the liver is a common diagnostic procedure. Although relatively safe, bleeding remains a potential complication and may occur more frequently in patients with coagulopathy. The purpose of this study was to evaluate the utility of a fibrin sealant in preventing bleeding after a 15-gauge needle biopsy of the liver in a canine model heparinized to simulate coagulopathy.

MATERIALS AND METHODS:

Fibrin sealant was delivered to biopsy tract sites in eight dogs anticoagulated with heparin (activated clotting time 387 seconds +/- 94) using the same sheath system that was employed to obtain the biopsy specimen.

RESULTS:

The results demonstrated complete hemostasis in the sealant-plugged tracts as compared to controls. Continuous bleeding was observed in none of the fibrin sealant-treated sites, compared with all of the control biopsy sites (P = .0078).

CONCLUSION:

These results demonstrate the high degree of efficacy of fibrin sealant delivered through a sheath system in plugging liver biopsy tracts and eliminating bleeding in a severely coagulopathic animal model. This indicates that fibrin sealant use in cutting needle biopsies can reduce major and minor complications associated with the procedure.

• Authors: J K Falstrom, M M Moore, S H Caldwell, A H Matsumoto, R D Abbott, W D Spotnitz
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 10 Issue 4 Pg. 457-62 (Apr 1999) ISSN: 1051-0443 [Print] United States
• PMID: 10229475 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticoagulants
• Fibrin Tissue Adhesive
• Hemostatics
• Tissue Adhesives
• Heparin

Topics

• Animals
• Anticoagulants (administration & dosage, adverse effects)
• Biopsy, Needle (adverse effects, instrumentation, methods)
• Disease Models, Animal
• Dogs
• Drug Delivery Systems
• Fibrin Tissue Adhesive (administration & dosage, chemical synthesis, therapeutic use)
• Hemorrhage (prevention & control)
• Hemostatics (administration & dosage, chemical synthesis, therapeutic use)
• Heparin (administration & dosage, adverse effects)
• Liver (pathology)
• Liver Diseases (prevention & control)
• Needles
• Syringes
• Tissue Adhesives (chemical synthesis, therapeutic use)