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Outcome of collagen vascular diseases by treatment with plasmapheresis.

Abstract
The outcome of collagen vascular diseases after treatment with plasmapheresis was studied in 9 patients with polyarteritis nodosa (PN), in 2 patients with Wegener's granulomatosis (WG), in 1 patient with allergic granulomatous angitis (AGA), and in 20 patients with systemic lupus erythematosus (SLE) associated with antiphospholipid syndrome (APS). Improvement after treatment with plasmapheresis was observed in 41.7% of the patients with PN, WG, and AGA. On the other hand, with the exception of 1 patient with thrombocytopenia and 1 patient with renal failure, all of the clinical manifestations, including thrombocytopenia, central nervous system (CNS) lupus, thrombophlebitis, lung infarction, and recurrent abortions in the SLE patients with APS, improved after plasmapheresis. Plasmapheresis is thought to be an influential strategy of treatment for patients with collagen vascular diseases.
AuthorsH Hashimoto, T Yano, T Kawanishi, H Tsuda, T Nagasawa
JournalTherapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis (Ther Apher) Vol. 2 Issue 4 Pg. 268-72 (Nov 1998) ISSN: 1091-6660 [Print] United States
PMID10227753 (Publication Type: Clinical Trial, Journal Article)
Topics
  • Adult
  • Antiphospholipid Syndrome (therapy)
  • Churg-Strauss Syndrome (therapy)
  • Female
  • Granulomatosis with Polyangiitis (therapy)
  • Humans
  • Lupus Erythematosus, Systemic (therapy)
  • Middle Aged
  • Plasmapheresis
  • Polyarteritis Nodosa (therapy)
  • Treatment Outcome

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