Abstract | BACKGROUND: Alcohol-induced bronchoconstriction is due to high blood concentrations of acetaldehyde, a metabolic product of ethanol, which lead to the release of histamine from basophils and mast cells. OBJECTIVE: METHODS: RESULTS: Of 13 asthmatic patients, five (38.5%) tested positive during an ethanol challenge test, represented by a fall more than 20% in FEV1. The responders had a high blood ethanol, and showed a rise in blood acetaldehyde and histamine concentrations, but not in LTC4 or TXB2. After azelastine treatment, there was no significant fall in FEV1 among responders. Neither the rise in blood ethanol nor blood acetaldehyde levels were blunted by treatment with azelastine, but the rise in blood histamine was blunted by this treatment. CONCLUSION: Our results suggest that antihistamine agents may be effective against alcohol-induced asthma by both blocking H1 receptors and inhibiting histamine release.
|
Authors | A Takao, T Shimoda, H Matsuse, K Mitsuta, Y Obase, S Asai, S Kohno |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 82
Issue 4
Pg. 390-4
(Apr 1999)
ISSN: 1081-1206 [Print] United States |
PMID | 10227338
(Publication Type: Journal Article)
|
Chemical References |
- Bronchoconstrictor Agents
- Bronchodilator Agents
- Phthalazines
- Leukotriene C4
- Ethanol
- Thromboxane B2
- Histamine
- Acetaldehyde
- azelastine
|
Topics |
- Acetaldehyde
(blood)
- Adult
- Aged
- Asthma
(chemically induced, metabolism)
- Bronchoconstrictor Agents
(antagonists & inhibitors, pharmacology)
- Bronchodilator Agents
(pharmacology)
- Ethanol
(adverse effects, blood)
- Female
- Histamine
(blood)
- Humans
- Leukotriene C4
(blood)
- Male
- Middle Aged
- Phthalazines
(pharmacology)
- Respiratory Function Tests
- Thromboxane B2
(blood)
|