Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors.

Abstract

To determine the role of growth factors in nonchemotherapy drug-induced agranulocytosis, we reviewed 118 published reports of administration of colony-stimulating factors for the disorder. Main outcomes were total duration of neutropenia and mortality. The mean time to neutrophil recovery was 4.6 +/- 3.2 days and 7.7 +/- 5.1 days in patients with a granulocyte count at diagnosis of 0.1-0.5 x 10(3)/mm3 and less than 0.1 x 103/mm3, respectively. The mortality rate was 4.2%. Without therapy with growth factors, the mean time to neutrophil recovery after discontinuation of the offending agent was reported to be 10 +/- 8 days. The mortality rate was 16% in one study. We conclude that hematopoietic growth factors may shorten the duration of neutropenia and reduce mortality in patients with severe drug-induced agranulocytosis.

• Authors: M F Beauchesne, S J Shalansky
• Journal: Pharmacotherapy (Pharmacotherapy) Vol. 19 Issue 3 Pg. 299-305 (Mar 1999) ISSN: 0277-0008 [Print] United States
• PMID: 10221368 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Colony-Stimulating Factors

Topics

• Adult
• Aged
• Agranulocytosis (chemically induced, therapy)
• Colony-Stimulating Factors (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Neutropenia
• Survival Analysis